Antiangiogenic effects of somatostatin and its analogues in rectal cancer

Abstract

Abstract: AIM: To investigate the correlation between the somatostatin analogues (SS) and angiogenesis in colorectal carcinoma.METHODS: 80 cases of colorectal carcinomas were examined by immunohistochemical staining (S-P method) using anti-SS, anti-VEGF and anti-CD34 (+) monoclonal antibodies.RESULTS: SS positive staining was obtained in 53 out of 80 cases (66.25 %), and mainly in the cytoplasm of tumor cells. Microvessel density (MVD) expression was more intense in the negative group in comparison with others (P < 0.01).A significant correlation was found between the SS, VEGF and TIMP-2.The expression of VEGF in the SS positive group was lower than that in the negative group (P <0.05), while that of TIMP-2 reversed (P < 0.05).CONCLUSION: There is certain antagonism between the expression of SS, VEGF and TIMP-2 in human colon cancer.One of the mechanisms of tumor inhibition by SS may be the interference with the synthesis of growth factors by tumor cells and with transmission of intracellular signals that regulates cell growth.

Key words: colorectal carcinoma, somatostatin, growth factors, rectal cancer

CLC Number:

R735.34

WU Jian, LI Xian-Hai, XIA Xiang-Hou, WANG Ya-Bin, YAN Jing-Yi. Antiangiogenic effects of somatostatin and its analogues in rectal cancer[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(3): 333-336.

References

1 刘福坤, 许哲, 黎介寿, 祁晓平, 李国立.结直肠癌术前、后化疗与手术总体治疗的临床研究[J].世界华人消化杂志, 1999;7:827-8
2 曹建彪, 李世荣.人乳头瘤病毒与结直肠癌的关系[J].世界华人消化杂志, 1999;7:1070-1
3 吴金生.结直肠癌术后局部复发与处理[J].华人消化杂志, 1998;6:810-1
4 Folkman J.Tumor angiogensis:therapeutie implication [J].N Engl JMed, 1971;285:1182-6
5 吴静, 樊代明.肿瘤血管生成与肿瘤血管抑制治疗[J].世界华人消化杂志, 2001;9(3):316-21
6 Schonbrunn A.Somatostatin receptors present knowledge and future directions[J].Ann Oncol, 1999;10(2):S17-21
7 Patel YC.Somatostatin and its receptor family [J].Front Neuroendocrinol, 1999;20:157-98
8 Larsson LI.Developmental biology of gastrin and somatostatin cells in the antropyloric mucosa of the stomach[J].Microsc. Res Tech, 2000;48:272-81
9 Smith AM, Watson SA.Gastrin and gastrin receptor activation: an early event in the adenoma-carcinoma sequence [J].Gut, 2000;47:820-4
10 Ohmori T, Asahi S, Sato C, Maki F, Masumoto A, Okada K. Bcl-2 protein expression and gut neurohormonal polypeptide/amine production in colorectal carcinomas and tumor-neighboring mucosa, which closely correlate to the occurrence of tumor [J].Histol Histopathol, 1999;14:37-44
11 黄象谦.生长抑素——— 可能是人体内影响最广泛的一个胃肠激素[J].华人消化杂志, 1998;6:93-6
12 Schonbrunn A.Somatostatin receptors present knowledge and future directions[J].Ann Oncol, 1999;10(2):S17-21
13 Pergo C, Lattuada D, Casnici C.Int J Immunopharmacol, 1998;20(9):479-90
14 Wang C, Tang C.Inhibition of human gastric cancer metastasis by ocreotide in vitro and in vivo[J].China Phearm Med Instrum, 2002;10;82(1):19-22
15 Buscail L, Vernejoul F, Faure P, Torrisani J, Susini C.Regulation of cell proliferation by somatostatin[J].Ann Endocrinol (Paris), 2002;63(2 Pt 3):2S13-8(Review)

[1]	SHI Dawei, ZHENG Xiaoyong, JIN Xiaodan, ZHAO Xiaoman, CHEN Jie, DU Xingjun. Implication of XPC rs2228001 polymorphism on the prognosis of patients with colorectal cancer who were treated with capecitabine-based adjuvant chemotherapy [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(4): 391-399.
[2]	WEI Zhenzhen, SUI Hua, JIANG Yulang, SUN Mingyu, YAN Huaru, WANG Ziyuan. Research on the molecular mechanism of Zuo Jin Wan combined with cetuximab inducing ferroptosis in KRAS mutant colorectal cancer cells [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(2): 130-137.
[3]	LIN Xueyan, LIN Zhihui, HUANG Huping. Effect of terlipressin on renal function in cirrhotic patients with esophageal gastric varices bleeding and normal baseline renal function [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(7): 775-784.
[4]	ZHOU Guangchen, LIU Yixi, ZHENG Yun. Colorectal cancer and microRNA: research progress [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(5): 575-587.
[5]	LI Yanyan, FANG Xiaojie, YIN Xin, SUN Xi, RAO Chunhui. circZNF124 regulates the proliferation, migration and invasion of colorectal cancer SW620 cells by targeting miR-4262 [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(11): 1231-1239.
[6]	LU Qiong, ZHU Haihong, QI Tingting, LI Guohua, TENG Xinqi, QU Qiang, QU Jian. OCTN2 gene polymorphisms affect the chemotherapeutic sensitivity of oxaliplatin in colorectal cancer [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2021, 26(4): 401-407.
[7]	ZHANG Dezhi, LIU Meng, ZHU Shaogong, LIU Guiju, JI Jie. Efficacy and safety of XELOX therapy in comparison with capecitabine monotherapy in adjuvant chemotherapy for elderly patients with colorectal cancer [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(8): 926-936.
[8]	WANG Ziyuan, SUN Mingyu. Advances in research on long non-coding RNA in drug resistance of colorectal cancer [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(7): 796-802.
[9]	SHI Lili, LIU Xingan, SHAN Guoyong. Efficacy and safety of apatinib in the further line treatment for patients with advanced colorectal cancer failed after standard therapy and the preliminary analysis of efficacy predictors [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(12): 1388-1394.
[10]	LI Rongzhen, MEI Jiazhuan, XIA Yunzhan, JI Jie. Prognostic factors and safety study of R0 resection colorectal cancer patients received capecitabine based adjuvant chemotherapy in real world [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(6): 704-711.
[11]	QIAO Dawei, LI Yufang, XIAO Yun, JIANG Lishuang, BO Ping. Research progress of Scutellaria barbata against colorectal cancer and its metastasis mechanism [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(3): 332-336.
[12]	BAI Yan, ZHENG Xiaoyong, YANG Yage, FANG Lifeng. Influence of programmed death-ligand 1 genetic variation on the clinical outcomes of postoperative CRC patients received 5-FU based adjuvant chemotherapy [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(2): 180-187.
[13]	LI Xiaojie,ZHANG Shengwei,WANG Huasheng,WANG Dong, MEI Jiazhuan, DENG Yewei. Effects of polymorphism of vascular endothelial growth factor A on the prognosis of colorectal cancer patients received fluorouracil based adjuvant chemotherapy [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(8): 900-904.
[14]	HU Yang, LI Zhixing, WANG Guo, ZHU Yuanshan. Research progress of lncRNA and chemotherapy resistance in colorectal cancer [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(4): 456-463.
[15]	ZHANG Yang, CHEN Zhikang, GUO Xiong, WANG Wen. Security observation of intraperitoneal perfusion chemotherapy with Raltitrexed in laparoscopic radical operation for colorectal cancer [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(3): 313-318.