Abstract: AIM: To study the effects of combination usage of amoxicillin (A), metronidazole (M) and colloidal bismuth subcitrate (B) on gastric ulcer in rats and to provide the clinical reasonable medication reference on peptic ulcer.METHODS: 40 rats were divided into 5 groups (n =8 in each): the test groups with the administration of mixture of A, M and B 225, 112 and 56 mg·kg^-1, respectively; the positive control group with the administration of cimetidine 112 mg·kg^-1and the negative control group with the administration of 2 % CMCNa. Two-thirds of rats in each group were given drugs before being made the gastric ulcer animal models induced by stress and pyloric ligation, and the other one-third of rats in each group were given drugs after being made the gastric ulcer models induced by acetic acid injury.RESULTS: The mixture prevented the formation of gastric ulcer induced by stress and pyloric ligation, and healed the gastric ulcer induced by acetic acid injury at the dosage of 112, 56 and 56 mg·kg^-1, respectively.CONCLUSION: The mixture can dose-dependently protect the gastric ulcer induced by stress, reduce the degree of gastric ulcer induced by pylorus ligation, and advance the healing rate of gastric ulcer induced by acetic acid injury, but its effect is lower than that of cimetidine.

Key words: amoxicillin, metronidazole, colloidal bismuth subcitrate, cimetidine, gastric ulcer