Abstract: AIM: To explore the correlation between Drug concentration of etoposide (VP16) and CYP3A activity (CA) in leukemia.METHODS: The urinary 6β-hydroxycortisol/hydrocortisone ratio is a useful marker for CA. Concentration of Vpl6 in plasma and CA was determined by HPLC in 20 leucemia patients, and the correla-tion analysis was performed using the SPSS software.RESULTS: Correlation analysis between drug concentration of VP16 and CA in leukemia was poor correlated (r=0.725), but concentration of VP16 and IGCA showed good correlated (r = 0. 969).CONCLUSION: It is feasible to adjust the therapeutic regimen of VP16 by determing CA.

Key words: etoposide, leukemia, CYP3A activity, Individuanlzation, dosage regimen