Abstract: Aim The effect of ciprofloxacin on the pharmaco-kinetics and the hypoglycemic effect of glipizide was studied.Methods Diabetic rats were given glipizide or glipizide combined with ciprofloxacin for nine days.Serum glipizide samples were assayed and pharmacokinetic parameters were analyzed.Results The concent ration-time curves in diabetic rats were fitted to one compartment model in both glipizide and glipizide combined with ciprofloxacin groups.The concentration of glipizide in glipizide combined with ciprofloxacin grouPwas elevated significantly.The clearance rate of the drug was declined by 50%(P<0.05), t_1/2(Ka)was prolonged by 63.7 % (P<0.05).After treatment of glipizide,or glipizide combined with ciprofloxacin,the blood glucose was 5.978 mmol·L^-1 or 5.301mmol·L^-1respectively. The difference of hypoglycemic effect between glipizide and glipizide combined with ciprofloxacin was significant. Conclusion The ciprofloxacin can affect the absorption of glipizide.The effect of lowering blood glucose of glipizide combined with ciprofloxacin is better than that of glipizide alone.

Key words: pharmacokinet ics, glipizide, ciprofloxacin