Anoxia-reoxygenation damage to rat ventricular myocytes and protective effects of tetramethylpyrazine1

Abstract

Abstract: Aim To observe anoxia-reoxygenation damage to ventricular myocytes and the protective effects of tetramethylpyrazine on the damage in rats.Methods T he myocytes viability,intracellular K⁺/Na⁺,intracellular free calcium concentration were detected in different tetramethylpyrazine concentration groups and control group in the anoxia-reoxygenation damage condition.Results Anoxia-reoxygenation had done harm to the rat ventricular myocytes.Tetramethylpyrazine inhibited the myocyte contracture,increased the cell via-bility,inhibited the fall of intracellular K⁺/Na⁺,and increased intracellular free calcium concentration in the dose of 4μmol·L^-1or more.And the more the dose is,the better the salutary effects are.Conclusions Tetramethylpyrazine has protective effect during anoxia-reoxygenation on the ventricular myocytes of rats.

Key words: tetramethylpyrazine, myocyte, anoxia-reoxygenation

CLC Number:

R285.5

CHEN Jiang-Bin, JIANG Hong, SUN Xiao-Mei, LI Geng-Shan, HUANG Cong-Xin, XU Jia-Li, TANG Qi-Zhu. Anoxia-reoxygenation damage to rat ventricular myocytes and protective effects of tetramethylpyrazine¹[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2000, 5(1): 18-20.

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Anoxia-reoxygenation damage to rat ventricular myocytes and protective effects of tetramethylpyrazine¹

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