Abstract: Aim To compare the bio availability of two ubiquinone tablets in healthy volunteers.Methods A HPLC method was used to determine the serum ubiquinone 10 concentrations at 0,1,2,3,4,6,8 and 12 h after oral administration for 7 day s (20 mg,tid)in a cross -over test.Results AUC,C_max and T_peak of the test tablets were (5.91±1.78)μg·h·ml^-1,(0.66±0.17)μg·ml^-1and (4.00±1.25)h,respectively,and these of the reference tablet s were (6.30±2.09)μg·h·ml^-1,(0.70±0.20)μg·ml^-1and (4.60±1.58)h,respectively.All of these parameters between the two kinds of tablets were not significantly different statistically.Conclusion The related bioavailability of the test tablet sversus the reference tablets is 93.9%.The two formulations of ubiquinone 10 are bioequivalent.

Key words: ubiquinone 10, tablets, bioavailability