Abstract: In clinical and experimental therapeutics, the quantitative analysis of drug interaction will supply a tool for optimizing and evaluating a combination in the study of compound drug, the design of combination drug therapy, and the evaluation of traditional medicine formu-lae. This paper listed the systematic methods of the quan-titative analysis, including the weighted modification method for optimizing constituents, doses and ratio in combination, the parameter method and the reflection method for dynamic analysis of drug interaction, and a comprehensive method for multiple response indexes.The software CoDrug about these methods also was introduced.

Key words: drug interaction, combination drug ther-apy, drug synergism, drug antagonism