Abstract: Aim To monitor the w hole blood trough concentration of cyclosporine A (CsA) in renal prednisone and to establish an optimal therapeutic window of CsA.Methods Samples were measured by specific fluorescence polarization immunoassay. According to the time after operation and different therapy plan, the whole blood trough concentration of CsA in each group was compared with that in control group.Results The optimal therapeutic window of CsA with MMF plan was 150~ 300 μg·L^-1(less than one month after operation)，120~ 260μg· L^-1(1~<3 mon) and 100~ 225 μg·L^-1(3 ~<6 mon).Conclusions The optimal therapeutic window of CsA with MMF plan are lower than control groups in the incidence of toxic effects and the rejection reaction is diminished obviously.

Key words: mycophenolate mofetil, cyclosporine A:renal transplants, clinic