Abstract: Aim To evaluate the clinical efficacy and safety of thrombolytic therapy for acute cerebral infarction. Methods Twenty-eig ht patients with acute cerebral infarction in the thrombotytic group were given an intravenous infusion of urokinase at the dose of 2 000 000 U and 30 patients received conventional therapy in the control group.Results Of the 28 cases, 4 recovered and 8 were markedly effective within 24 hours, while none of the 30 patients was effective. After 14 days, 12 patients in the thromboly tic group and one in the convent ional therapy group cured.The effective rate in the thromblytic group was higher than that in the conventional therapy group.Statist ical dif ference was found between the two groups. Conclusion Early int ravenous thromboly tic therapy with urokinase shows remarkable efficacy for acute cerebral infarction.

Key words: cerebral infarction, urokinase, thrombolytic therapy