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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 1998, Vol. 3 ›› Issue (2): 127-128.

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Effect of benazepril on hypertensive left ventricular hypertrophy and ventricular arrhythmias

WANG An-Cai, JI Qin-Jiong, ZHU Xiang-Ming   

  1. Department of Cardiology, Yijishan Hospital, Wannan Medical College, Wuhu 241001
  • Received:1998-04-10 Online:1998-06-26 Published:2020-12-01

Abstract: Aim To invest igate theEffect of benazepril on hypertensive left ventricular hypertrophy(LVH)and ventricular a rrhy thmias (VAs).Methods Thecardiac shape and arrhy thmic prevalencc were detected by 24h ambulatory electrocardiographic monitoring and Colour Dopplerechocardiog rphy beforeand 6 months after taking benazepril in 56 cases of hypertensive patients.Results Theincidences of VAs and Lown's grade ≥3 ve ntricular arrhy thmias were 77.7 % and 48.1 % in 27 cases with LVH, significantly higher than 34.4 % and 10.3 % in 29 cases without LVH (P<0.01).Remarkableregression of IVS, LVPW and LVMI was found after half yeartreatment of benazepril (P<0.05 or 0.01), so did LA (P<0.01).Meanwhile, theincidence of VAs, particularly complexventricular ar rhy thmias was significantly decreased.Conclusion Benazepril has a favorable Effect on hypertnsive left ventricular hypertrophy and ventricular a rrhy thmias.

Key words: benazepril, hypertensive disease, left ventricular hypertrophy, ventricular arrhythmias

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