Abstract: Aim The effect of liqustrazin on myocardial ischemia leperfusion injury in rats was observd. Methods The rat model of myocardial ischemia tepeifusion was established by ligating coro-nary artery. The rats were randomly divided in the control, model and liqustrazin treated groups. The activities of SOD, GSH · PX, Ca²⁺-ATPase, K⁺, Na⁺ ATPase and contents of MDA and Ca²⁺ were observed respectively. Results In the liqustrazin treated group as compared with those of the model, the activities of SOD, GSH · PX, Ca²⁺ ATPase, K⁺, Na⁺ -ATPase in the myocardial membrane increased significantly (P ＜0.01 or P ＜0.05) w hile contents of MDA and Ca²⁺ decreased (P ＜0.01) significantly. Activities of SOD and GSH · PX in the mitochondria was also increased (P ＜0.01) and MDA content decreased (P ＜0.01). Conclusions Liqustrazin has notable protective effects on myocardial-ischemia leperfusion injury in rats, which is due to its scarenging oxygen free radicals and anti ipid peroxydation reaction.

Key words: liqustrazin, myocardium, ischemia Teperfusion injury, oxy free radicals, adenosine triphosphatase, lipid peroxydation