Abstract: Aim The effect of naloxone (NAL) on human renal postischemic reperfusion in vitro was observed. Methods Six human kidneys in two groups were reperfused separately by either normal perfusion solution or the solution added by 0.8 μg/ml of naloxone. Malondialdehyde (MDA) and superoxide dismutase (SOD) in the reperfusion solution and Na⁺, K⁺-ATP ase and Ca²⁺-ATPase in the renal tissue were determined. The histopathological structure of kidneys was obseved. Results All the above parameters in the treatment had no significant difference from those in the control group. Conclusion NAL had no obvious effect on human renal postischemic reperfusion in vitro. It was supposed that though NAL had protective effect on renal postischemic reperfusion in vivo, it did not directly affect the kidney.

Key words: naloxone, postischemic reperfusion