Abstract: Aim To observe the effects and safety of co-artemether and one of its components benflumetol (two formulations) for treatment of patients with plasmodium falciparum. Methods 150 patients was recruited, with 51 patients in coartemether group (A), 50 patients in benflumetoltablet group(B), 49 patients in benflumetol group (C), The methods of double-blinding, radomization and comparison were applied and all patients were conditioned and observed for 28 days. Results The mean fever clearance time for group A, Band C was 17.1±8.6,34.0±23.2 and 29.4±24. 9 hours respectively; mean parasite clearance time was 29.7±,51.6±14.1 and 54.7±17.4 hours respectively and the cure rate for group A,B and C was 98.22% 92.0% and 95.8% respectively. No significant side-effects was observed and no significant change was found in laboratory test. Conclusion Coartemether and one of its components benflumetol (2 formulations) have good curative effect for patients with plasmodium falciparum, but coartemether is more effective than benflumetol (2 formulations) in velocity for controling symptoms and killing parasites.

Key words: co-artemether, artemether, benflumetol, plasmodium falciparum