Abstract: Aim The mechanism of caleium channel entry blockers (CCEB) in protecting the liver from ischemia-reperfusion injury was to be explored. Methods With establishment of hepade ischemia-reperfusion injury (HIRI) model, the effects of verapamil (VP) and diltiazem(DT) on xanthine oxidase (XO), superoxide dismutase (SOD) activities and concentration of lipid peroxides (LPO) in the liver tissue and plasma during HIRI were dynamically observed in rabbits. Results The group treated with VP or DT, as com-pared with the control group, showed that XO activity and LPO content all decreased significantly (all P<0.0l)t but there was no difference for SOD activity between VP group and control group or DT group and control group (all P>0.05),. Conclusion It is indicated that mechanism of the protection afforded by CCEB was closely related to its decreasing XO activity and inhibiting lipid peroxidation during HIRI.

Key words: calcium channel entry blockers, xanthine oxidase, lipid peroxides, is-chemia-reperfusion injury