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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2006, Vol. 11 ›› Issue (3): 342-344.

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Tissue distribution of brucine in mice

LI Xiao-tian, ZHANG Li-rong1, WANG Tian-kui2, WANG Hong-juan, JIA Xin   

  1. College of Pharmacy,1College of medicine,ZhengzhouUniversity,Zhengzhou 450052,Henan,China;
    2Henan Electric Power Hospital,Zhengzhou 450052,Henan,China
  • Received:2006-01-06 Revised:2006-02-20 Online:2006-03-26 Published:2020-12-04

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Abstract: AIM: To study the tissue distribution of brucine in mice.METHODS: After ig and iv administration of brucine at doses of 60 and 10 mg·kg-1 in mice,the plasma and tissue concentrations at different time points were determined by fluorescence spectrophotometry.RESULTS: After ig and iv administraction,The main tissue distribution of brucine in mice was similar,the brucine concentrations in the liver and kidney were the highest and those in the spleen,heart,lung,brain,stomach,fat and muscle decreased sequentially.CONCLUSION: There is an extensive distribution of brucine in mice and it has ability to permeate blood brain barrier.

Key words: brucine, tissue distribution, fluorescence spectrophotometry

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