Effect of ipratropium bromide on ventilation weaning in COPD patients

Abstract

Abstract: AIM: To study the effect of increasing ipratropium bromide (IB) dosage in the morderated to severe degree COPD patients with difficultly ventilation weaning.METHODS: Observed the effects of high dosage(120μg one time) ipratropium bromide in 17 patients with morderated to severe degree COPD who were fail to ventilation weaning at giving the routine dose (80μg one time) ipratropium bromide.RESULTS: All 17 patients were weaned ventilator successfully.The patients' indexes of artery blood gas analysis with giving high dosage IB were higher than those with routine dosage IB,the patients'modify Borg scores and respiration rates,heart rates with high dosage IB were lower than those with routine dosage IB(P<0.01),no further side effect for increasing IB dosage was observed.CONCLUSION: When the expiratory resistance becomes the most important factor of delaying ventilation weaning,giving a high dosage IB during ventilation weaning period may helPmorderate to severe degree COPD patients weaning the ventilator.

Key words: chronic obstructive pulmonary disease, ipratropium bromide, M anticholinergy receptor, ventilator, ventilation weaning

CLC Number:

R969

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