Abstract: AIM: To compare the synergistic effect of eupolyphaga on chemotherapeutics of digestive canal cancer.METHODS: Drug sensitivity of stomach cancer cell(BGC-823) was determined in vitro by MTT anti-tumor screening assay for eupolyphaga with HCPT,5-Fu,Oxa,docelaxel,by comparing cell inhibition,the synergistic effect of eupolyphaga was analysed to find the best synergistic drug.RESULTS: The synergistic effects of eupolyghaga were more significant in HCPT and Oxa than those of 5-Fu and docelaxel in vitro (P<0.05).CONCLUSION: Eupolyphaga has a higher sensitivity in clinical routine chemotherapeutic regimens for stomach neoplamas cells in vitro.

Key words: eupolyphaga, chemotherapeutic on stomach cancer, synergistic effect, anti-tumor