Abstract: Aim The serum bactericidal action (SBA)of cefotaxime and its clinical effect were observed and compared with two schedules of antimicrobial chemotherapy in patients with hematopathy complicated by infection.Methods Thirty patients in 3 groups were treated with cefotaxime (CTX), piperacillin plus amikacin (PIP + AN)and cefoperazone (CPZ)respectively.The SPA was determined by microdiluted method and the clinical effect was judged according to the records of symptoms and clinical effect was judged according to the records of symptoms and clinical findings recorded before and after treatment.Results In comparison with CPZ and PIP + AN, CTX had better SBA and longer antimicrobial time.As to against defferent strains of infection-causing bacteria the SBA of CTX to Ps aeruginose and E cloacea was weak, while PIP + AN had a broader antimicrobial spectrum, but the antibacterial time of PIP was short.Among the three antimicrobials there was no statistical defference in clinical effect.Conclusion To enhance the efficacy and reduce adverse reaction the dosing time should be regulated.It is recommended that piperacillin and cefoperazone be given three times daily, cefotaxime twice a day and amikacin once a day.

Key words: hematopathy serum bactericidal activity(SBA), cefotaxime, cefoperazone, piperacillin, amikacin.