Effect of sodium-calcium exchanger and its inhibitors on arrhythmia

Abstract

Abstract: In cardiomyocytes, sodium-calcium exchanger (NCX) is regarded to play an important role in the regulation of intracellular Ca²⁺concentration.During the cardiac ischemia reperfusion or cardenolide intoxication, the inflow Ca²⁺through NCX reverse mode induce calcium overload and arrhythmia.Recently, the benzyloxyphenyl derivatives have been developed as selective NCX inhibitors, which may have therapeutic potential as a new remedy for arrhythmias.

Key words: sodium-calcium exchanger, reverse mode, calcium overload, sodium-calcium exchanger inhibitor, arrhythmia

CLC Number:

R541.7
R962

SHEN Lei, WU Yu-lin. Effect of sodium-calcium exchanger and its inhibitors on arrhythmia[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(6): 610-613.

References

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