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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2006, Vol. 11 ›› Issue (6): 640-643.

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Inhibitory effects of carboxymethyl-chitosan on proliferation and in vitro metastatic ability in human highly metastatic lung carcinoma 95-D Cells

YANG Jing-ya, LIU Jian-wen1, LIU Cheng-chu, CHEN Bi-wen   

  1. College of Food Science, Shanghai Fisheries University, Shanghai 200237, China;
    1College of Pharmacology, East-China University of Science and Technology, Shanghai 200093, China
  • Received:2006-05-30 Revised:2006-06-09 Online:2006-06-26 Published:2020-12-04

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Abstract: AIM: To study the inhibitory effects of carboxymethyl-chitosan on proliferation and metastatic ability in human highly metastatic lung carcinoma 95-D Cells.Methods: The inhibitory effect of carboxymethyl-chitosan on the migration of 95-D cells was tested by cell migration assay.Cell invasion was analyzed by the matrigel invasion assay.Soft agar colony formation assay and adhesion assay were also used to evaluate the suppression of carboxymethyl-chitosan on 95-D cells.Results: Carboxymethyl-chitosan dose-dependently inhibited the soft agar colony formation, migration, invasion, adhesion and proliferation of 95-D cells.Conclusion: Carboxymethyl-chitosan can significantly repress the proliferation and in vitro metastasis of 95-D cells.

Key words: carboxymethyl-chitosan, metastasis, lung carcinoma

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