Abstract: AIM: Tofind out a more effective therapy to cure diabetic renopathy through observing whether combination of angiotensin converting enzyme inhibitor (ACEI) and angiotensin Ⅱ antagonist (ARB) treatment is more effective than that of using single medicine.Methods: Seventy-two selected patients were divided into three groups in which are ACEI group (representative medicine is monopril, ARB group (representative medicine is valsartan) and ACEI+ARB group (representative medicines are monopril and valsartan.The period of treatment is 8 weeks.The 24-hour uric albumen examination was detected before and after the treatment.Results: No significant difference showed before the treatment (P>0.05).There was significant difference in the decrease of the amount of 24-hour urine protein examination before and after the treatment among three groups.Compared with the single drug group, the effects of the combination group was better.Conclusion: Using monopril or valsartan solely or the combination of monopril and valsartan can decrease the 24-hour urine protein effectively. The effect of monopril and valsartan are same.However, the effect of the combination group was better than the two single drug groups.

Key words: angiotensin converting enzyme inhibitor, angiotensin Ⅱantagonist, diabetic renopathy, 24-hour urine protein examination