Change of decreasing blood pressure on pain threshold of spontaneously hypertensive rats

Abstract

Abstract: AIM: To study the effect of decreasing blood pressure on mechanical and heat pain sensitivity in spontaneously hypertensive rats.METHODS: 15 SHRs were intramuscularly given reserpine (1 μg·kg ^-1·d ^-1) on day 4-11.Blood pressure, paw withdrawal mechanical threshold (PWMT) and paw withdrawal thermal latency (PWTL) were measured every day.RESULTS: After the therapy of reserpine in spontaneously hypertensive rats, blood pressure decreased by 50 mmHg, mechanical and heat pain threshold were both decreased (P < 0.05).CONCLUSION: Spontaneously hypertensive has reversible effect on spontaneously hypertensive rat nociceptive system.

Key words: blood pressure, pain threshold, paw withdrawal mechanical threshold, paw withdrawal thermal latency

CLC Number:

R541.3

LIU Xiao-yu, WU Dang-fang, ZHOU Yan, LI Jie, ZHANG Yan-hai. Change of decreasing blood pressure on pain threshold of spontaneously hypertensive rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(4): 474-476.

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Change of decreasing blood pressure on pain threshold of spontaneously hypertensive rats

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