Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2021, Vol. 26 ›› Issue (3): 350-360.doi: 10.12092/j.issn.1009-2501.2021.03.016
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CHEN Xuli, WEI Jing, WANG Jiabing
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Abstract: In recent years, the role of inhibitor kappa B kinaseβ (IKKβ) in the process of tumorigenesis has gradually been elucidated. IKK is involved in tumor cell proliferation and survival by acting on multiple molecular pathways. Inhibition of IKKβ has been identified as a promising treatment for cancer. Researchers have developed a series of IKKβ inhibitors and found that they can effectively inhibit tumor growth, but no IKKβ inhibitors have been used clinically to treat cancer. We discuss progress in understanding the role of IKKβ in tumorigenesis and review the recent development of main inhibitors of IKKβ.
Key words: inhibitor kappa B kinaseβ, inhibitor kappa B kinaseβ inhibitors, tumorigenesis
CLC Number:
R73
R965.2
CHEN Xuli, WEI Jing, WANG Jiabing. Advances in understanding the role of IKKβ in tumorigenesis and its inhibitors[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2021, 26(3): 350-360.
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URL: https://manu41.magtech.com.cn/Jweb_clyl/EN/10.12092/j.issn.1009-2501.2021.03.016
https://manu41.magtech.com.cn/Jweb_clyl/EN/Y2021/V26/I3/350