Abstract: AIM: To study protective effects of the extract from Toona sinensis seeds on gastric mucosal injury in experimental mice.  METHODS: The mice were given 200 mg/kg, 400 mg/kg of Toona sinensis seeds every day for 2 weeks and ethanol or aspirin was used to induce gastric mucosa injury model. The gastric mucosal injury index and injury inhibition rate were calculated, the levels of SOD, MDA in serum and the contents of ET-1, PGE2 and NO in gastric mucosal tissues were determined to explore protective effects of Toona sinensis seeds on mucosa injury. RESULTS: After 14 days of prevention administration, Toona sinensis seeds could significantly reduce the gastric mucosa injury index induced by ethanol and aspirin. The inhibition rate of ethanol-induced gastric mucosa injury in the two dose groups was 40.4% and 47.4%, and that of aspirin -induced gastric mucosa injury was 38.9% and 44.6%. The inhibitory rate of cimetidine on ethanol and aspirin-induced gastric mucosa injury was 50.9% and 50.2%, respectively. In addition, compared with the model animal group induced by ethanol and aspirin, the doses of 200 and 400 mg/kg of Toona sinensis seeds could increase the levels of SOD, PGE2 and NO in the gastric mucosal tissues of mice, and reduce the contents of MDA and ET-1. CONCLUSION: The extract of Toona sinensis seeds has a certain protective effect on the injury of gastric mucosa in mice caused by ethanol and aspirin.

Key words: the extract of Toona sinensis seeds, ethanol, aspirin, gastric mucosa injury, protective effect