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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2024, Vol. 29 ›› Issue (8): 955-960.doi: 10.12092/j.issn.1009-2501.2024.08.018

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Research progress of molecular docking in screening anti-cervical cancer drugs

WANG Dan1, ZHANG Wenyan1, LUO Renjie 1, CHEN Yuanjing1, HAN Xue2, QU Bo2, FENG Shifang2, NIE Xiazi2, LIU Huiling2   

  1. 1The First Clinical College of Gansu University of Traditional Chinese Medicine,2 Department of Gynecology, Gansu Provincial People's Hospital, Lanzhou 730000, Gansu, China
  • Received:2023-10-08 Revised:2023-11-06 Online:2024-08-26 Published:2024-07-17

Abstract:

Cervical cancer is one of the most common gynecological malignant tumors,the five-year survival rate decreased significantly in the case of lymph node metastasis and distant metastasis,so the development of new anti-cervical cancer drugs is of great significance for the treatment of cervical cancer.Molecular docking technology is one of the most commonly used research methods in computer aided drug design,which is widely used in screening the effective components of drugs, finding the targets of drugs acting on tumors and exploring the mechanism of antineoplastic drugs. This paper reviews the molecular docking technology in the screening of anti-cervical cancer drugs,the determination of anti-tumor targets and the mechanism of anti-cervical cancer,in order to provide more sufficient theoretical basis for the screening of anti-cervical cancer drugs and new drug research and development.

Key words: cervical cancer, molecular docking, virtual screening, target protein, action mechanism

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