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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2024, Vol. 29 ›› Issue (12): 1380-1388.doi: 10.12092/j.issn.1009-2501.2024.12.008

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Advances in diagnosis, treatment and management of hypertriglyceridemia in pregnancy

LI Zhimin1,2, LI Shiran1,2, XIE Jingxian1,3, ZHANG Jiao1,2,4, LI Pengfei1,2,5, ZENG Siyu1,2, YANG Yong1,2   

  1. 1 Department of Pharmacy, Sichuan Academy of Medical Sciences-Sichuan Provincial People's Hospital/University of Electronic Science and Technology of Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan, China; 2 Sichuan Key Laboratory of Individualized Pharmacotherapy, University of Electronic Science and Technology of China School of Medicine, Chengdu 610054, Sichuan, China; 3 School of Pharmacy, Southwest Medical University, Luzhou 646000, Sichuan, China; 4 Department of Pharmacy, Chongqing Red Cross Hospital (Jiangbei People's Hospital), Chongqing 400020, China; 5 Department of Pharmacy, Bishan Hospital, Chongqing Medical University, Chongqing 402760, China
  • Received:2024-06-19 Revised:2024-07-22 Online:2024-12-26 Published:2024-11-18

Abstract:

Hypertriglyceridemia (HTG) during pregnancy may cause serious complications such as acute pancreatitis, gestational diabetes mellitus, and preeclampsia, especially the high mortality rate of maternal acute pancreatitis is of concern.The physiologic increase in triglyceride (TG) levels during pregnancy poses a challenge for the diagnosis of HTG, there are no diagnostic criteria for pregnant women. The management of HTG in pregnancy remains focused on early screening and a scientifically based fat-restricted diet. Omega-3 fatty acid therapy may be considered for those who cannot be controlled after strict dietary restriction and lifestyle changes, and fibrates may be  used in late pregnancy when the benefits outweigh the risks, as appropriate, and plasma exchange may be a safe and effective option for extremely severe patients. TG levels in early pregnancy are associated with maternal postpartum and neonatal prognosis. Further studies on pharmacologic treatments and management for HTG in pregnancy are expected.

Key words: hypertriglyceridemia, pregnancy, pregnancy complications

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