Recent progress of aldose reductase in non-diabetic disease

Abstract

Abstract: Aldose reductase belongs to aldo-keto reductase superfamily, which catalyzes the rate limiting step of the polyol pathwany. To date, emerging reports have suggested that aldose reductase mediates intracellular signal transduction pathways that triggered by cytokines, growth factors and oxidative stress. Then aldose reductase is involved in various of pathological processes of diseases. This paper summarized the role of aldose reductase in the non-diabetic diseases.

Key words: Aldose reductase, Diabetes mellitus, Non-diabetic disease

CLC Number:

R977.3

DENG Xiao-lan, LI Hui, JING Xian, TIAN Ying-ying, LV Pei-yu, OUYANG Dong-sheng. Recent progress of aldose reductase in non-diabetic disease[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(5): 590-594.

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