Progresses of AEG-1 on cancer research

Abstract

Abstract: Astrocyte-elevated gene-1 (AEG-1), a novel oncogene, has been implicated in several crucial aspects of tumor progression, including oncogenic transformation, evasion of apoptosis, proliferation, invasion, metastasis, angiogenesis, chemoresistance and protective autophagy. Human AEG-1 gene is located in chromosome 8q22, which is known to be a hot spot for genomic alterations in several cancer cells. AEG-1 is regulated by Ras/PI3K/Akt/c-Myc pathway and exerts its effects by activating various pathways such as PI3K/Akt, NF-κB, Wnt/β-catenin, MAPK and so on. Since its clinical significance and biological role in human cancers, AEG-1 provides a novel target for intervening in the cancer phenotype. This article reviewed the current progress in the research field of AEG-1 in human tumor.

Key words: AEG-1, Human tumor, Molecule pathway

CLC Number:

R969.1

HAO Gang, ZHOU Fang, WU Xiao-lan, WANG Guang-ji. Progresses of AEG-1 on cancer research[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(6): 679-687.

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