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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2011, Vol. 16 ›› Issue (6): 716-720.

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Clinical research advancement of nanoparticle albumin-bound paclitaxel in anti-cancer treatment

CAI Xin-jun, XU Ying-ying, NI Jian-jun   

  1. Department of Pharmacy,Integrated Chinese and Western Medicine Hospital of Zhejiang Province,Hangzhou 310003,Zhejiang,China
  • Received:2011-05-04 Revised:2011-05-12 Published:2011-07-25

Abstract: Albumin is a vital drug carrier for nanoparticle paclitaxel in the anti-cancer treatment.This paper reviewed the pharmacokinetics and mechanism of nanoparticle transport of nanoparticle albumin-bound paclitaxel,and summarized the recent clinical trials of nanoparticle albumin-bound paclitaxel in breast cancer,non-small cell lung cancer,and other malignant treatment which could be a reference for its clinical use.

Key words: Paclitaxel, Nanoparticle albumin-bound, Clinical trial

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