Meta-analysis of flurbiprofen on preemptive analgesic effect

Abstract

Abstract: AIM: Meta analysis of preoperative use of flurbiprofen on postoperative analgesia efficacy and safety. METHODS: 15 articles were sieved into the pump out of according to set a comprehensive search of the database search methods and research into the proposed standard from 267 documents, applications RevMan 5.0 software into the pump after the literature 4 h, 24 h two time points Meta-analysis of VAS score. RESULTS: 15 articles of the heterogeneity test showed the results of trials was significantly (P<0.05), select the random effects model analysis. Meta analysis showed that the forest plan: post- operative 4 h, 24 h of VAS combined effect of the amount of test score were statistically significant in analgesic effect between flurbiprofen group and control group (P<0.05). The number of patients in the combined adverse effects of the amount of testing was not statistically significant, still could not believe that flurbiprofen group and control group differences in adverse reactions. CONCLUSION: The available clinical data indicate that preoperative use of flurbiprofen can reduce postoperative pain, patients still can not believe that could reduce the incidence of adverse reactions.

Key words: Flurbiprofen, Preemptive analgesia, Meta analysis

CLC Number:

R311

ZHANG Xu-tong, HUANG Zhi-lian, LI Xing-wang, LI Jun. Meta-analysis of flurbiprofen on preemptive analgesic effect[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(9): 1006-1011.

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