Comparison of calsurf and curosurf on preterm infants respiratory distress syndrome

Abstract

Abstract: AIM: To evaluate and compare the efficacy and safety of pulmonary surfactant, calsurf and curosurf, on the treatment of preterm infant respiratory distress syndrome (RDS).METHODS: From January 2008 to August 2011,120 case of preterm infant RDS diagnosed and treated in the neonatal intensive care unit of our hospital were randomly devided into two groups, calsurf treatment group and curosurf treatment group, each including 60 cases, given calsurf and curosurf treatment though trachea cannula, respectively, observed the efficacy and complications.RESULTS: Both calsurf and curosurf had positive treatment effectiveness on RDS, represented for improvement the ventilator parameters, blood gas analysis results and RDS grade, respectively (P<0.05). The effects of curosurf was much better than calsurf especially for the duration of mechanical ventilation and oxygenization (P<0.05). There were no differences in complications of preterm infants between the two groups (P<0.05).CONCLUSION: Both calsurf and curosurf have positive effectiveness and good safety in the treatment of RDS, curosurf has efficacy advantage while calsurf has economic advantage.

Key words: Pulmonary surfactant, Respiratory distress syndrome, Preterm infant, Efficacy

CLC Number:

R722

DONG Yi-hui, YUAN Xian-wen, LI Peng. Comparison of calsurf and curosurf on preterm infants respiratory distress syndrome[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(1): 97-102.

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