Abstract: AIM: To study the effects of Salbutamol aerosol inhalation prior to anesthesia induction on lung collapse during one lung ventilation in patients with chronic obstructive pulmonary disease.METHODS: Fourty patients with concomitant chronic obstructive pulmonary disease, scheduled for lobectomy were randomly allocated into observation group(n=20) and control group(n=20) . Salbutamol aerosol 200 μg (two puffs) were administered according to instructions before oxygenation via mask in observation group, whereas in control group no aerosol was given before oxygenation via mask. Anesthesia induction was initiated after 30 minutes' oxygenation in both groups. Extent of lung collapse was evaluated by verbal scale in 10 minutes and 20 minutes after one lung ventilation. Blood gas analysis was assayed in baseline, before anesthesia induction, double lung ventilation and 30 minutes during one lung ventilation(every 10 minutes was performed).RESULTS: There was statistical significance in lung collapse score between observation group and control group(P<0.05), the former was superior to the latter.Compared with the control group, the value of PaCO₂ in anesthesia induction, double lung ventilation, 10 minutes and 20 minutes after one lung ventilation were lower than that in observation group, however , the value of PaO₂ were higher in respective time.CONCLUSION: Salbutamol aerosol inhalation can accelerate lung collapse in early stage of one lung ventilation and at the same time provide better surgical access condition in patients with chronic obstructive pulmonary disease.

Key words: Salbutamol, Chronic obstructive pulmonary disease, One-lung ventilation, Lung collapse