Abstract: AIM: To identify the content of GABA in peri-implantation mouse uterine and its effects on decidualization by intraperitoneal injection different concentration of GABA.METHODS: The contents of GABA in peri-implantation mouse uterine from day 1 to day 8 were measured by chromatometry. From day 5, 0.05 g/kg,0.5 g/kg,5 g/kg concentrations of GABA were injected by abdominal cavity until day 8. Decidual tissues were weighted and then made paraffin section followed by HE staining. Areas of decidual were measured by Image J software.RESULTS: The contents of GABA in the pregnancy of D3 utrerine upregulated followed decreased in D4 utrerine but the highest content of GABA was occurred in D5 implantion sites uterine compared with that of in D1 utrerine. The content of GABA from D6 to D8 utrerine in iner- implantion sites were higher than implantion sites. Both 0.05 g/kg GABA and 5 g/kg GABA could reduced the number of deciduum, while both 0.5 g/kg GABA could down-regulated the weight of deciduum. Both 0.05 g/kg GABA and 0.5 g/kg GABA could reduce the area of decidual region.CONCLUSION: The contents of GABA showed dynamic change in peri-implantation mouse uterine which may be invloved in inhibited decidualization.

Key words: γ-Amino butyric Acid, Chromatometry, Decidualization