Effects of extracellular-signal regulated kinsae signaling pathway on myocardial ischemia/reperfusion injury

Abstract

Abstract: It has been suggested that extracellular-signal regulated kinsae (ERK), an important subfamily of mitogen-activated protein kinases (MAPKs), plays a pivotal role in modulating cell growth, differentiation, stress and death. Multiple studies showed that: during myocardial ischemia/reperfusion (I/R) injury ex vivo and in vivo, ERK becomes activated and plays a key role in inducing cell survival or cell damage, which might be dependent on the type of cell and the degree and duration of I/R. In this review we focus on the role of ERK pathway in myocardial I/R injury.

Key words: Extracellular-signal regulated kinsae, Ischemia/reperfusion injury, Cardiomyocytes

CLC Number:

R542.2

CHEN Gao-yong, ZHANG Yan-mei, SHI Gang-gang. Effects of extracellular-signal regulated kinsae signaling pathway on myocardial ischemia/reperfusion injury[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(2): 234-240.

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