Welcome to Chinese Journal of Clinical Pharmacology and Therapeutics,Today is Chinese

Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2012, Vol. 17 ›› Issue (3): 269-273.

Previous Articles     Next Articles

Effects of HSYA injection on platelet aggregation, ultrastructure and the content of PAF induced GMP-140 in PRP in rabbits

XU Lu, DONG Zhi   

  1. Chongqing Medical University, Pharmaceutical Scienses, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing 400016, China
  • Received:2011-11-21 Revised:2012-02-10 Online:2012-03-26 Published:2012-04-20

Abstract: AIM: To observe the effects of HSYA injection on platelet aggregation and ultra structure in rabbits. METHODS: In vivo experiments, when platelet activating factor (PAF) induced respectively, we observed the impacts of HSYA injection (10 mg/kg, 5 mg/kg and 2.5 mg/kg) on platelet aggregation, ultra structural changes of platelets and PAF-induced content of GMP-140. RESULTS: HSYA injection inhibited AA and PAF-induced platelet aggregation(P<0.05,P<0.01). Scanning electron microscope showed: HSYA injection could reduce the number of aggregation type plateles which were induced by AA and PAF; and make fewer and shorter processes of dendritic platelets(P<0.05,P<0.01). HSYA injection can reduce the content of GMP-140 in PRP(P<0.01). CONCLUSION: HSYA injection can antagonism PAF-induced platelet aggregation, inhibit the activation of platelets and reduce the content of GMP-140. Thus for, there will be more choices for clinical using of anti-platelet aggregation drugs.

Key words: HSYA, Platelets, Electron microscopy, GMP-140, PAF

CLC Number: