Abstract: AIM: To investigate the safety and feasibility of dezozine in gynecological laparaoscopy under epidural anesthesia. METHODS: Sixty ASAⅠorⅡpatients, aged 18-55 yr, undergoing gynecological laparoscopy surgery, were randomly divided into 2 groups (n=30 each): Dezocing group (group D) and Fentanyl group (group F). P_ETCO₂ and Ramsay sedation scales were recorded at the time points followed: pre-anesthesia (T₀), 10 min after administration (T₁), instantly after pneumoperitoneum (T₂), 30 min (T₃) and 60 min (T₄) after pneumoperitoneum, 5 min after eliminating pneumoperitoneum (T₅). The incidences of side effects such as nausea, vomiting, algor and respiratory depression was observed. RESULTS: Ramsay sedation scales were not statistically different between the two groups. D group's P_ETCO₂ was lower than of F group at the time points of T₃ and T₄. The incidences of nausea, vomiting and respiratory depression were higher in F group (P<0.05). CONCLUSION: Dezocine has significant advantages over fentanyl to assist epidural anesthesia in gynecological laparoscopy with respect to reduce discomfort during pneumoperitoneum, better analgesia and sedation, less side effects.

Key words: Dezocine, Fentanyl, Epidural anesthesia, Gynecological laparoscopy