Role of P-glycoprotein in neurodegenerative disease

Abstract

Abstract: Neurodegenerative disease is a form of chronic progressive neurological disease based on neuronal degeneration, and its pathogenesis is not clear, but the abnormal aggregation and deposition of some exogenous and endogenous substances are closely related to its cause, and it is usually the P-glycoprotein substrate. In recent years, studies have shown that the expression of P-glycoprotein on blood-brain barrier will be reduced in some neurodegenerative disease, which may lead to further aggregation and sedimentation of pathogenic exogenous and endogenous to deteriorate the condition. In this paper, the role played by the P-glycoprotein in the pathogenesis of neurodegenerative disease and disease progression is reviewed

Key words: P-glycoprotein, Neurodegenerative disease, Alzheimer's disease, Parkinson's disease

CLC Number:

R741

ZHANG Mi, ZHANG Qi-zhi, LOU Jiang, ZENG Han-qing, PENG Wen-xing. Role of P-glycoprotein in neurodegenerative disease[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(7): 835-840.

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