Abstract: AIM: To investigate the efficacy of combination treatment with clofazimine and other antituberculosis drugs for patients with multi-drug-resistant tuberculosis. METHODS: 72 cases with multi-drug-resistant tuberculosis were randomly divided into experimental group (n=32) and control group (n=40). The treatment effect was observed at the 6th month and 18th month after treatment. RESULTS: 6 months later, the sputum negtive conversion rate in smear and in culture were 81.3% and 84.4% respectively and the rate in X-rays focus absorption was 37.5% in experimental group, which were significantly higher than those in control group. CONCLUSION: Combination treatment with clofazimine and others for patients with multi-drug-resistant tuberculosis can improve the curative effect and shorten course of treatment especially in the stage strengthened.

Key words: Clofazimine, Multi-drug-resistant Tuberculosis, Efficacy, Antituberculosis drugs