Research progress on the PK evaluation of anti-cancer nano-preparation

Abstract

Abstract: The poor water-solubility and pharmacokinetics of anticancer drugs will cause significant problems during clinical application.Developing nano-preparations is a reliable and safe way to improve the water solubility and pharmacokinetics of anticancer drugs, which possesses a promising prospect in both research and application in recent years. On the basis of recent studies, the pharmacokinetics of nano-preparation in vivo and in vitro and the mechanisms underlying the advantages of nano-preparations are reviewed in this paper.

Key words: Drug delivery system, Multidrug resistance, Nano-Preparation

CLC Number:

LUO Dan, ZHANG Jing-wei, ZHOU Fang, WU Xiao-lan, WANG Guang-ji. Research progress on the PK evaluation of anti-cancer nano-preparation[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(2): 205-211.

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