Abstract: AIM: To investigate the efficacy of CO₂ laser combined with ALA photodynamic therapy for recurrent perianal Condyloma Acuminatum.METHODS: Forty-six patients with perianal Condyloma Acuminatum were randomly divided into two groups, experimental group for the CO₂ laser combined with ALA photodynamic therapy (ALA-PDT), first with CO₂ laser dispel wart body, exposing out photodynamic laser treatment, once a week for three consecutive times; control group for the CO₂ laser treatment group, visually the wart was completely cleared.One week after the treatment for efficacy evaluation,all patients were followed up to evaluate the recurrence rate within 3 months after treatment.RESULTS: After treatment, the warts were completely disappear, the recurrence rate of experimental group and control group was 19%,65%,respectively.CONCLUSION: CO₂ laser combined with ALA photodynamic therapy for recurrent perianal Condyloma Acuminatum is safely and effectively, can reduce the relapse rate.

Key words: Condyloma acuminatum, Aminolevulinic acid hydrochloride, Photodynamic therapy