Inhibitor of thrombin, bivalirudin

Abstract

Abstract: Bivalirudin was approved by US Food and Drug Administration as a new direct inhibitor of thrombin in 2000, the drug was currently approved the application to PCI / PTCA, HIT / HITTS, ACS etc. Existing research shows bivalirudin have a better security and can be used for the classic treatment regimens ( heparin and glycoprotein IIb/IIIa inhibitors ) alternative treatment, Moreover, it can reduce the risk of bleeding and mortality. This paper analysis the mechanism of action, pharmacokinetics, pharmacodynamics, clinical application, safety and cost-effectiveness of bivalirudin. But it limited in application in the domestic market, thus strengthening the clinical trails research is promising.

Key words: Bivalirudin, Direct inhibitor of thrombin, Clinical trail, Cost-Effectiveness

CLC Number:

HE Yan, WANG Liang-you. Inhibitor of thrombin, bivalirudin[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(3): 339-343.

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