Abstract: AIM: To investigate the serum high sensitive creactive protein(hs-CRP), cathepsin S (CatS) level changes and clinical significance in acute coronary syndrome patients. METHODS: All patients were divided into acute coronary syndrome (ACS group,n=53) and control group(n=36).The levels of serum hs-CRP and CatS in two groups were detected and compared before and after treatment.RESULTS: There were no significant difference of two groups in gender, age, smoking, diabetes, cerebral infarction, hypertension prevalence rate. The levels of serum CatS and hs-CRP in ACS group before treatment and control group were (0.51±0.03) nmol/L,(10.21±5.03) mg/L and (0.43±0.04) nmol/L,(3.64±1.87) mg/L,respectively;there were statistically significant differences(P<0.05).After treatment,the levels of serum CatS and hs-CRP in ACS group were (0.45±0.06) nmol/L and (6.05±3.25) mg/L, compared with before treatment (0.51±0.03) nmol/L and (10.21±5.03) mg/L, which were significantly decreased, there were statistically significant differences(P<0.05).CONCLUSION: Changes of hs-CRP, CatS level in ACS patients suggest that hs-CRP and CatS may play an important role in acute coronary syndrome, CatS may possibly act as a new biomarker of ACS.

Key words: Cathepsin S, Acute coronary syndrome, High sensitive creactive protein