Clinical observation of Lobaplatin combined with Irinotecan in the treatment of extensive-stage disease small-cell lung cancer

Abstract

Abstract: AIM: To investigate the effects and side effects of Lobaplatin plus Irinotecan regimens in the treatment of patients suffered from extensive stage disease small-cell lung cancer (ED-SCLC).METHODS: 25 patients suffered from ED-SCLC were treated by Lobaplatin 35 mg/m² i.v.d1 plus Irinotecan 80 mg/m2 i.v.d1,8, every 3 weeks. Efficacy was estimated by imaging every 2 cycles.RESULTS: In 25 evaluable patients,CR was 4% (1/25),PR was 36% (9/25), SD was 28%(7/25), and PD was 32% (8/25). The objective response rate(ORR)was 40% . The disease control rate (DCR) was 68%. The median progression free survival (PFS) was 5.3 months. The median overall survival(OS) was 7.6 months. The most commonly seen adverse events(AEs) were myelosuppression and diarrhea. There was no treatment-related death.CONCLUSION: The treatment of Lobaplatin plus Irinotecan shows an effective antitumor activity and a favorable toxicity profile in patients with ED-SCLC.

Key words: Small-cell lung cancer, Lobaplatin, Irinotecan

CLC Number:

R734.2

XIAO Xiao-guang, CHEN Yuan. Clinical observation of Lobaplatin combined with Irinotecan in the treatment of extensive-stage disease small-cell lung cancer[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(9): 1049-1052.

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