Effect of candesartan on HOMA-IR and serum adiponectin of spontaneously hypertensive rats

Abstract

Abstract: AIM: To investigate the effect of candesartan, an angiotensin II receptor antagonist, on HOMA-IR and serum adiponectin of spontaneously hypertensive rats(SHRs).METHODS: SHRs were divided into two groups: Hypertension group (SHR, n=30), Candesartan group (Candesartan, 1 mg·kg^-1·d^-1, n=30, gavaging for 12 weeks).WKY rats were the control group(WKY, n=30). The other two groups were given a placebo. Fasting blood glucose and serum insulin were measured by biochemistry methods, insulin resistance index (HOMA-IR) was calculated,OGTT was tested by biochemistry methods. Changes of serum adiponectin were measured by ELISA.RESULTS: No difference in the fasting blood glucose of the three groups (P>0.05) was observed. Serum insulin level and HOMA-IR of SHRs were higher than those of WKY and drug groups (P<0.05). Candesartan could not reduce those of SHRs. Serum adiponectin level of SHRs was lower than that of WKY, and candesartan could obviously increase that of SHRs (P<0.05). The result of OGTT showed that blood glucose level at 30 min or 120 min in hypertension group compared with control group and candesartan group were higher.CONCLUSION: Candesartan could ameliorate the upregulaiton of serum adiponectin in SHR, improve insulin resistance and reduce blood glucose level of SHR at 30 min and 120 min.

Key words: Candesartan, Adiponectin, Spontaneously hypertension, Glycometabolism

CLC Number:

R965.2

LI Xiao-yan, ZHANG Ping, TAO Ling, LIU Yu-xing. Effect of candesartan on HOMA-IR and serum adiponectin of spontaneously hypertensive rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(11): 1201-1204.

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