Overview and progress on the study of the pharmacokinetics of naringin

Abstract

Abstract: Naringin is a dihydroflavone compound with the function of promoting gastrointestinal motility, which was found in some Chinese medicine such as Fructus Aurantii, Fructus Aurantii Immaturus, Rhizoma Drynariae, Pummelo Peel and so on. Naringin's oral absorb was bad, extensive distributed in the body, and produced metabolin like p-hydroxybenzoic acid and p-hydroxycinnamic acid by the way of opening loop, dehydrogenation, splitting, then eliminated from the body. Naringin also could interact with other drugs with the inhibiton of some transporters and metabolic enzymes, then influenced the pharmacokinetics of other drugs. This text reviews the pharmacokinetics of naringin and it's influence on other drugs, then points out that the mechanism of interaction through the metabolic process and the influence of genetic polymorphism on its pharmacokinetics still need to be studied.

Key words: Naringin, Pharmacokinetic, Drug interaction

CLC Number:

R969.1

ZHU Hong-ping, XIONG Yu-qing. Overview and progress on the study of the pharmacokinetics of naringin[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(11): 1297-1303.

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