Research progress on the relationship between calcium-independent phospholipase A2 and myocardial ischemia/reperfusion

Abstract

Abstract: Calcium-independent phospholipase A₂ (iPLA₂) is a subfamily of phospholipase A₂ (PLA₂), which plays an important role in signal transduction and phospholipid remodeling. Although PLA₂ enzymes were first purified from cobra venom and have been known for over 100 years, only within the last 20 years has their importance in physiologic and pathologic processes been widely recognized. Meanwhile, over the past 15 years, more and more studies have showed that iPLA₂ was activated and played a significant role in myocardial ischemia and reperfusion (I/R). In this review, the functional role of iPLA₂ in I/R is the focus.

Key words: Calcium-independent phospholipase A₂, I/R, Activity control, Arachidonic acid

CLC Number:

WAN Xing, SHI Gang-gang. Research progress on the relationship between calcium-independent phospholipase A₂ and myocardial ischemia/reperfusion[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(11): 1304-1309.

References

[1] McHowat J, Creer MH. Catalytic features, regulation and function of myocardial phospholipase A₂ [J]. Cardiovasc Hematol Agents Med Chem, 2004, 2(3): 209-218.
[2] 杨磊, 孟庆雄. 磷脂酶A₂的研究进展 [J]. 食品与药品, 2007, 9(7): 52-54.
[3] Murakami M, Kudo I. Phospholipase A₂ [J]. J Biochem, 2002, 131(3): 285-292.
[4] Hazen SL, Ford DA, Gross RW. Activation of a membrane-associated phospholipas A₂ during rabbit myocardial ischemia which is highly selective for plasmalogen substrate [J]. J Biochem, 1991, 266(9): 5629-5633.
[5] Williams SD, Hsu FF, Ford DA. Electrospray ionization mass spectrometry analyses of nuclear membrane phospholipid loss after reperfusion of ischemic myocardium [J]. Lipid Res, 2000, 41(11): 1585-1595.
[6] Williams SD, Gottlieb RA. Inhibition of mitochondrial calcium-independent phospholipaseA₂ (iPLA₂) attenuates mitochondrial phospholipid loss and is cardioprotective [J]. Biochem J, 2002, 362(3): 23-32.
[7] 陈高勇, 张艳美, 石刚刚. ERK信号转导通路在心肌缺血再灌注中的作用 [J]. 中国临床药理学与治疗学, 2012, 17(2): 234-240.
[8] Cedars A, Jenkins CM, Mancuso DJ, et al. Calcium independent phospholipases in the heart: mediators of cellular signaling, bioenergetics and ischemia-induced electrophysiologic dysfunction [J]. J Cardiovasc Pharmacol, 2009, 53(4): 277-289.
[9] Murakami M. Hot topics in phospholipase A₂ field [J]. Biol Pharm Bull, 2004, 27(8): 1179- 1182 .
[10] Yang B, Gwozdz T. Orai1 and Ca²⁺-independent phospholipase A₂ are required for store-operated Icat-SOC current, Ca²⁺ entry, and proliferation of primary vascular smooth muscle cells [J]. Am J Physiol Cell Physiol, 2012, 302(5): C748-756.
[11] Smani T, Domínguez-Rodríguez A. Role of Ca²⁺-independent phospholipase A₂ and store-operated pathway in urocortin-induced vasodilatation of rat coronary artery [J]. Circ Res, 2007, 101(7): 1194-1203.
[12] Jenkins CM, Cedars A, Gross RW. Eicosanoid signalling pathways in the heart[J]. Cardiovasc Res, 2009, 82(8): 240-249.
[13] Beckett CS, Pennington K, McHowat J. Activation of MAPKs in thrombin-stimulated ventricular myocytes is dependent on Ca²⁺ -independent PLA₂ [J]. Am J Physiol Cell Physiol, 2006, 290(12): C1350-C1354.
[14] Lei X, Barbour SE, Ramanadham S. Group VIA Ca²⁺-independent phospholipase A₂β (iPLA₂β) and its role in β-cell programmed cell death [J]. Biochimie, 2010, 92(6): 627-637.
[15] Shinzawa K, Tsujimoto Y. PLA₂ activity is required for nuclear shrinkage in caspase-independent cell death[J]. J Cell Biol, 2003, 163(6): 1219-1230.
[16] Portilla D, Crew MD. cDNA cloning and expression of a novel family of enzymes with calcium-independent phospholipase A₂ and lysophospholipase activities [J]. J Am Soc Nephrol, 1998, 9(4): 1178-1186.
[17] Takatani-Nakase T, Takahashi K. Cardioprotective activity of urocortin by preventing caspase- independent, non-apoptotic death in cultured neonatal rat cardiomyocytes exposed to ischemia [J]. Biochem Biophys Res Commun, 2010, 402(2): 216-221.
[18] Hsu YH, Dumlao DS, Cao J, et al. Assessing phospholipase A₂ activity toward cardiolipin by mass spectrometry [J]. PLos One, 2013, 8(3): e59267.
[19] 张鹭, 张浩. 磷脂酶A₂及其功能概述[J]. 齐齐哈尔医学院学报, 2004, 25(2): 178-180.
[20] Zachman DK, Chicco AJ. The role of calcium-independent phospholipase A₂ in cardiolipin remodeling in the spontaneously hypertensive heart failure rat heart [J]. J Lipid Res, 2010, 51(3): 525-534.
[21] Akiba S, Sato T. Cellular function of calcium-independent phospholipase A₂ [J]. Biol Pharm Bull, 2004, 27(8): 1174-1178.
[22] Jesús B, Rebeca P, Balboa MA. Calcium-independent phospholipase A₂ and apoptosis [J]. Biochimica et Biophysica Acta, 2006, 1761(2): 1344-1350.
[23] Song H, Wohltmann M, Tan M, et al. Group VIA PLA₂ (iPLA₂β) is activated upstream of p38 mitogen-activated protein kinase (MAPK) in pancreatic islet β-cell signaling [J]. J Biol Chem, 2012, 287(8): 5528-5541.
[24] Ho JN, Lee SB, Lee SS, et al. Phospholipase A₂ activity of peroxiredoxin 6 promotes invasion and metastasis of lung cancer cells [J]. Mol Cancer Ther, 2010, 9(4): 825-832.
[25] Liu SJ, Mchowat J. Stimulation of different phospholipase A₂ isoforms by TNF-α and IL-1β in adult rat ventricular myocytes [J]. Am J Physiol, 1998, 275(6): H1462-H1472.
[26] Moon SH, Jenkins CM, Liu X, et al. Activation of mitochondrial calcium-independent phospholipase A₂γ (iPLA₂γ) by divalent cations mediating arachidonate release and production of downstream eicosanoids [J]. J Biol Chem, 2012, 287(18): 14880-95.
[27] Reutenauer-Patte J, Boittin FX, Patthey-Vuadens O, et al. Urocortins improve dystrophic skeletal muscle structure and function through both PKA- and Epac-dependent pathways [J]. Am J Pathol, 2012, 180(2): 749-762.
[28] Xie Z, Liu D. Identification of a cAMP-response element in the regulator of G-protein signaling-2 (RGS2) promoter as a key cis-regulatory element for RGS2 transcriptional regulation by angiotensin II in cultured vascular smooth muscles[J]. J Biol Chem, 2011, 286(52): 44646-44658.
[29] Sun B, Zhang X. Inhibition of calcium-independent phospholipase A₂ activates p38 MAPK signaling pathways during cytostasis in prostate cancer cells [J]. Biochem Pharmacol, 2010, 79(12): 1727-1735.
[30] Aoto M, Shinzawa K. Essential role of p38 MAPK in caspase-independent, iPLA(2)-dependent cell death under hypoxia/low glucose conditions [J]. FEBS Lett, 2009, 583(10): 1611-1618.

Research progress on the relationship between calcium-independent phospholipase A₂ and myocardial ischemia/reperfusion

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 4

Recommended Articles

Metrics

Comments

[1]	WAN Xing, SHI Gang-gang. Research progress on the relationship between calcium-independent phospholipase A₂ and myocardial ischemia/reperfusion [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(11): 1303-1309.
[2]	DONG Liu-yi, CHEN Zhi-wu. Myocardial ischemia/reperfusion injury and inflammatory reaction [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(5): 582-588.
[3]	WANG Guo-feng, CHEN Dong-mei. Neuroprotective effects of paeoniflorin against cerebral ischemia through pharmacological preconditioning [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(5): 504-511.
[4]	HUANG Wei-jia, CHEN Shou-quan, WANG Wan-tie, LI Hui-ping, CHENG Jun-yan, ZHAO Chuhuan, LI Zhang-ping, WANG Ming-shan, WANG Wei. Effect of Xingnaojing injection on metabolism of arachidonic acid in rabbits following cerebral ischemia-reperfusion injury [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(10): 1171-1174.