Prevalence and risk factors for chronic kidney disease in Wuhu

Abstract

Abstract: AIM: To investigate the prevalence and risk factors associated with chronic kidney disease (CKD) in Wuhu, China. METHODS: To investigate the prevalence and risk factors associated with chronic kidney disease (CKD) in Wuhu, China. RESULTS: The result showed the prevalence of CKD in Wuhu city was 6.71%. The prevalence of proteinuria, hematuria, and eGFR of less than 60 mL·min^-1·1.73 m^-2 were 1.83%, 2.07%, and 3.4% respectively, all of which were increased expectedly with age. multivariate analysis demonstrated hyperuricemia, diabetes, anemia, age,gemdre and hypertension (OR 2.28, 1.70, 1.65, 1.48, and 1.29, respectively) to be independent risk factors for CKD. CONCLUSION: CKD in Wuhu city is lower than the average CKD prevalence in China as a whole. The risk factors for CKD outlined above should considered as a potential strategy for the early identification and prevention of CKD.

Key words: chronic kidney disease, prevalence, risk factor

CLC Number:

R965.2

YANG Yan-lang, ZHONG Zheng-ling, WANG Yu-wei, GAO Chao-qing, JING Yue-long, ZOU He-qun. Prevalence and risk factors for chronic kidney disease in Wuhu[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(4): 430-436.

References

[1] Xue JL, Ma JZ, Louis TA, et al. Forecast of the number of patients with end-stage renal disease in the United States to the year 2010[J]. J Am Soc Nephrol, 2001,12(12):2753-2758.
[2] 侯凡凡,马志刚,梅长林,等.我国五省市、自治区慢性肾脏病患者心血管疾病的危险因素调查[J].中华医学杂志,2005, 85(11):753-758.
[3] Zhang L, Wang F, Wang L, et al. Prevalence of chronic kidney disease in china: a cross-sectional survey[J].lancet,2012, 379(9818):815-822.
[4] Ma YC, Zuo L, Chen JH, et al. Modified glomerular filtration rateestimating equation for Chinese patients with chronic kidneydisease[J].J Am Soc Nephrol,2006,17(10): 2937-2944.
[5] K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification[J]. Am J Kidney Dis,2002,39(2 supp1): S1-266.
[6] 杨沿浪,邹和群,汪裕伟,等. 两种肾小球滤过率评价公式评价健康体检人群慢性肾脏病患病率的对比研究[J]. 南方医科大学学报,2013, 33(9): 1347-1351.
[7] Cepoi V, Onofriescu M, Segall L, et al. The prevalence of chronic kidney disease in the general population in Romania: a study on 60,000 persons[J]. Int Urol Nephrol, 2012,44(1):213-220.
[8] Ohno Y, Ishimura E, Naganuma T, et al. Prevalence of and factors associated with chronic kidney disease (CKD) in Japanese subjects without notable chronic diseases, undergoing an annual health checkup[J]. Kidney Bood Press Res, 2012, 36(1):139-148.
[9] Shan Y, Zhang Q, Liu Z et al. Prevalence and risk factors associated with chronic kidney disease in adults over 40 years: a population study from Central China[J]. Nephrology,2010,15 (3): 354-361.
[10] Chen W, Chen W, Wang H, et al. Prevalence and risk factors associated with chronic kidney disease in an adult population from southern China[J]. Nephrol Dial Transplant,2009, 24(4): 1205-1212.
[11] 张路霞, 左力, 徐国宾, 等. 北京市石景山地区中老年人群中慢性肾脏病的流行病学研究[J]. 中国肾脏病杂志, 2006,22(2): 67-71.
[12] Shen P, He L, Li Y, et al. Natural history and prognostic factors of IgA nephropathy presented with isolated microscopic hematuria in Chinese patients[J]. Nephron Clin Pract,2007,106(4): c157-c161.
[13] Yamagata K, Takahashi H, Tomida C, et al. Prognosis of asymptomatic hematuria and/or proteinuria in men. High prevalence of IgA nephropathy among proteinuric patients found in mass screening[J]. Nephron,2002,91(1): 34-42.
[14] Liu Q, Li Z, Wang H, et al. High prevalence and associated risk factors for impaired renal function and urinary abnormalities in a rural adult population from southern china[J]. Plos One, 2012,7(10):e47100.
[15] Wu Y, Huxley R, Li L, et al. Prevalence, awareness, treatment, and control of hypertension in China: data from the China National Nutrition and Health Survey 2002[J]. Circulation, 118(25):2679-2686.
[16] Jiang L, Liang Y, Qiu B,et al. Prevalence of chronic kidney disease in a rural chinese adult population: the handan eye study[J]. Nephron Clin Pract, 2010,114(4): c295-302.
[17] Levey AS, Stevens LA, Schimid CH, et al. A new equation to estimate glomerular filtration rate[J]. Ann inter Med, 2009, 150(9): 604-612.
[18] 中华医学会肾脏病分会透析移植登记工作组. 1999年度全国透析移植登记报告[J]. 中华肾脏病杂志,2001, 17: 77-78.
[19] Baylis C. Age-dependent glomerular damage in the rat. Dissociation between glomerular injury and both glomerular hypertension and hypertrophy. Male gender as a primary risk factor[J]. J Clin Invest, 1994,94(5): 1823-1829.
[20] Kitiyakara C, Yamwong S, Vathesatogkit P, et al. The impact of different GFR estimating equation on the prevalence of CKD and risk group in a Souheast Asian cohort using the new KDIGO guidelines[J]. BMC Nephrol, 2012, 6(13):1-9.
[21] Obemayr RP, Temml C, Gutjahr G, et al. Elevated uric acid increases the risk for kidney disease[J]. J Am Soc Nephrol, 2008, 19(12):2407-2413.
[22] Weiner DE, Tighiouart H, Elasyed EF, et al. Uric acid and incident kidney disease in the community[J]. J Am Soc Nephrol,2008,19(6):1204-1211.
[23] Kanellis J, Watanabe S, Li JH, et al.Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2[J]. Hypertension, 41(6):1287-1293.
[24] Nakagawa T, Kang DH, Feig D, et al. Unearthing uric acid: An ancient factor with recently found significance in renal and cardiovascular disease[J].Kidney Int, 2006, 69(10):1722-1725.
[25] Keane WF, Zhang Z, Lyle PA, et al. Risk scores for predicting outcomes in patients with type 2 diabetes and nephropathy: the RENAAL study[J].Clin J Am Soc Nephrol, 2006, 1(4): 761-767.
[26] Mohanram A, Zhang Z, Shahinfar S, et al. Anemia and end-stage renal disease in patients with type 2 diabetes and nephropathy[J].Kidney Int,2004, 66(3):1131-1138.
[27] Chen N, Wang W, Huang Y, et al. Community-based study on CKD subjects and the associated risk factors[J]. Nephrol Dial Transplant,2009,24(7): 2117-2123.
[28] Guh JY, Chen HC, Tsai JF, et al. Herbal therapy is associated with the risk of CKD in adults not using analgesics in Taiwan[J].Am J Kidney, 2007,49(5): 626-633.
[29] Su T, Zhang L, Li X, et al. Regular use of nephrotoxic medications is an independent risk factor for chronic kidney disease-reslut from a Chinese population study[J].Nephrol Dial Transplant,2011,26(6): 1916-1923.