Abstract: AIM: To study the effect of acetylcysteine taurine magnesium salt [(NAC·TA)Mg]on lipid metabolism in rats with non-alcoholic steatohepatitis (NASH). METHODS: 95 male SD rats were randomly divided into 2 groups:the normal group,the model group.The experimental rats were given fat rich diet.The model of NASH was established after 12 weeks. All the rats were put to death after 8 weeks treatment,plasma sample was collected for the content detection of serum ALT,AST,triglyceride(TG),total cholesterol(TC),the high-density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C).RESULTS: Compared with the model group,the contents of ALT,AST,TG,TC or LDL-C were significantly decreased, the conten of HDL-C was increased,the differences had remarkable significance(P<0.05 or P<0.01).CONCLUSION: (NAC·TA)Mg can obviously decrease the content of blood-fat in rats with NASH.

Key words: acetylcysteine taurine magnesium salt, non-alcoholic steatohepatitis, lipid metabolism