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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2014, Vol. 19 ›› Issue (11): 1281-1287.

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Genetic variation of cytochrome P450 oxidase and personalized medicine

LV Pei-yu1, YUAN Hong3, ZHOU Hong-hao1, 2, OUYANG Dong-sheng1, 2   

  1. 1 Department of Clinical Pharmacology, Xiangya Hospital, Central South University;
    2 Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan,China;
    3 Center of Clinical Pharmacology of the Third Xiangya Hospital of Central South University, Changsha 410013, Hunan,China
  • Received:2014-04-21 Revised:2014-05-21 Online:2014-11-26 Published:2014-12-09

Abstract: Genetic polymorphisms of cytochrome P450 oxidase is an important cause of individual differences in drug metabolism. Only very few of the reported mutations are functional. We review the research progress of mechanized functionally related gene polymorphisms of cytochrome P450 oxidase to provide a reference for drug individualized treatment.

Key words: cytochrome P450 oxidase, gene polymorphism, drug metabolism, personalized medicine

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