Abstract:

AIM: To observe the efficacy of Quetiapine and Annao Tablet in treating delirium superimposed dementia. METHODS: 100 dementia patients with delirium were randomly divided into the experimental group (administered with Quetiapine and Annao Tablet) and control group (administered only with Quetiapine), 50 cases in each group. The Delirium Rating Scale (DRS), the Brief Psychiatric Rating Scale (BPRS), Mini-mental State Examination (MMSE) and Activity of Daily Living Scale (ADL) were evaluated before treatment and at the 3rd, 6th, 9th, 12th, 15th day after treatment, respectively. Adverse reactions were recorded. RESULTS:1 case in experimental group and 3 cases in control group were dropped. The DRS scores of experimental group were higher than those of control group at the 3rd and 9th day after treatment (P<0.05), the DRS scores of experimental group were much higher than those of control group at the 6th day after treatment (P<0.01). The BPRS scores of experimental group were much lower than those of control group at the 3rd and 6th day after treatment (P<0.01).The BPRS scores of experimental group were lower than those of control group at the 9th day after treatment (P<0.05). The MMSE scores of experimental group were much higher than those of control group after treatment (P<0.01). The ADL scores of experimental group were lower than those of control group after treatment (P<0.05). There's no statistical difference in incidence rate of adverse reactions between the two groups (P>0.05). CONCLUSION: The combination treatment of Quetiapine and Annao Tablet had a rapid reaction to dementia patients with delirium, which also could improve the patients' cognitive and social function.

Key words: Quetiapine, Annao Tablet, delirium, dementia